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Test E ( Testosterone Enanthate) 250 mg Magnus Pharmaceuticals | GAS-0261

50.00€
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Indications for use

In men, Testosterone enanthate is used in hormone replacement therapy for disorders associated with testosterone deficiency:

delayed puberty; eunuchoidism, underdevelopment of the genitals; endocrine impotence; hypopituitarism; symptoms of male menopause (decreased libido, mental and physical activity); post-castration syndrome (androgen deficiency after castration); osteoporosis due to androgen deficiency.

In women, the indications for use are:

hyperestrogenism, functional bleeding; uterine fibroids; endometriosis; menopause (in combination with estrogens); breast cancer; osteoporosis.

Contraindications

Increased individual sensitivity to the components of the drug, prostate or breast carcinoma; prostatic hypertrophy with symptoms of impaired urination; nephrosis or nephrotic phase of nephritis, edema; hypercalcemia; impaired liver function; diabetes mellitus; heart and coronary insufficiency, a history of myocardial infarction, atherosclerosis in elderly men; pregnancy, breast-feeding.

How to use: dosage and course of treatment

Testosterone enanthate is injected intramuscularly, deep into the gluteal muscle. The dosage regimen is selected individually, depending on the disease, gender, age, and clinical effect.

  • As a rule, adults are administered intramuscularly 50-200 mg after 2-4 weeks.
  • It is not recommended to exceed the dose of 400 mg per month. The duration of treatment is set individually.
  • With hypogonadism in men as eunuchoidism, the recommended dose is 50-400 mg every 2-4 weeks.
  • With delayed puberty, 50-200 mg is used every 2-4 weeks 4-6 months.
  • For breast cancer in women: 200-400 mg every 2-4 weeks.
  • The drug can not be administered intravenously!

Pharmacological action

Testosterone enanthate is an ester of testosterone.

Testosterone is the primary male sex hormone synthesized and secreted by the testicles. It stimulates the growth and development of the male genitals and secondary sexual characteristics (maturation of the prostate, seminal vesicles, penis and scrotum), the distribution of male-type hair on the face, pubis, chest), the development of the larynx, body muscles and fat distribution. It retains nitrogen, sodium, potassium and phosphorus, increases anabolism and reduces protein catabolism. Premature increase in the concentration of testosterone in the blood plasma in the period before puberty causes the closure of the epiphyses and the suspension of growth. It stimulates the production of erythropoietin and red blood cells. By the mechanism of negative feedback, it inhibits the secretion of luteinizing and follicle-stimulating hormones of the pituitary gland and inhibits spermatogenesis. In men with primary hypergonadotropic hypogonadism, the level of gonadotropins is normalized.

In women, it inhibits the gonadotropic function of the pituitary gland, the function of the ovaries, mammary glands, and causes endometrial atrophy. The antagonistic effect in relation to estrogens is used in the treatment of fibroids, endometriosis, breast cancer. It shows a favorable effect on complaints of the menopausal period.

Side effects

Priapism and other signs of excessive sexual stimulation (frequent erections); in boys in the prepubertal period-accelerated sexual development, increased frequency of erections, penis enlargement and premature closure of the epiphysis; damage to spermatogenesis and impaired maturation of sperm, oligospermia and a decrease in the volume of ejaculate; prostate abnormalities.

in women - bleeding from the birth canal, increased libido; with prolonged use of the drug, symptoms of virilization are possible; hirsutism, gynecomastia; seborrhea, acne, oily skin, accelerated hair loss; sodium and water retention, edema; symptoms of hypercalcemia; thrombophlebitis; nausea, cholestatic jaundice, increased levels of liver aminotransferases (as they stop taking it, they normalize); headache, depression, aggressiveness, anxiety, sleep disorders, paresthesia.

Possible pain, itching and hyperemia at the injection site.

In acute overdose, the toxicity of testosterone is extremely low.

With a chronic overdose, priapism may develop. In this case, treatment should be discontinued, and after the symptoms disappear - start in smaller doses.

Special instructions

In the event of androgen-dependent adverse reactions, testosterone treatment should be discontinued. After the side effects disappear, resume treatment at lower doses.

Patients with latent or severe heart failure, impaired renal function, hypertension, epilepsy or migraine (or a history of these conditions) should be constantly monitored, since androgens can in some cases cause sodium and water retention. With prolonged use, check the liver function. In patients with breast cancer, hypernephroma, lung cancer with bone metastases, check the level of calcium in the blood and urine.

In boys in the prepubertal period, androgens should be used with caution to avoid premature closure of the epiphyses and accelerated sexual development

Interaction

Increases the effectiveness of anticoagulants and hypoglycemic agents (it is necessary to change the dose), inhibits the elimination of cyclosporine. Inducers of liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin) reduce the effect of testosterone.

Specifications
Active substance Testosterone, Testosterone enantato
Active ingredient, mg 250
Release form Bottle
1 bottle, ml 10
Bottles in the package, pcs 1
Manufacturer Magnus Pharmaceuticals

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