Sindoxil (Sustanone) 250 mg AdamLabs | GAS-0253

Sindoxil (Sustanone) 250 mg by AdamLabs

Sindoxil (Sustanone) 250 mg AdamLabs is a natural anti-cancer drug obtained semi-synthetically from a plant, binding to plasma proteins is 88-98%. The half-life from blood to tissue is 30 minutes. It easily penetrates and is adsorbed by tissues, accumulates mainly in the liver, spleen, pancreas, stomach, intestines, heart and muscles.

Effect Sindoxil (Sustanone) by AdamLabs

It is metabolized in the liver by hydroxylation with the participation of cytochrome P450 isoenzymes CYP2D8 (with the formation of the metabolite-6-alpha-hydroxypaclitaxel) and CYP3CA4 (with the formation of the metabolites 3-para-hydroxypaclitaxel and 6-alpha, 3-para-dihydroxypaclitaxel).

T1 / 2 and total clearance are variable and depend on the dose and duration of intravenous administration: 13.1-52.7 h and 12.2-23.8 l / h / m2, respectively.

90% of the drug is excreted in the bile in the form of metabolites. In a small amount (from 1.3 to 12.6%, depending on the level of the administered dose), it is excreted in the urine in an unchanged form.

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Dosage Sindoxil (Sustanone) 250 mg in England

The recommended dose of Syndaxil for the treatment of Kaposi's sarcoma in AIDS patients is 100 mg / m2 as a 3-hour infusion every 2 weeks. The administration of Syndaxil should not be repeated until the neutrophil content is at least 1500/µl of blood, and the platelet content is at least 100,000/µl of blood.

In patients who have experienced severe neutropenia after taking Sindoxil (Sustanone) 250 mg or severe peripheral neuropathy during subsequent courses of treatment, the dose of Syndaxil should be reduced by 20%.

The drug solution is prepared immediately before administration by diluting the concentrate with 0.9% sodium chloride solution, or 5% dextrose solution, or 5% dextrose solution in 0.9% sodium chloride solution for injection, or 5% dextrose solution in Ringer's solution to a final concentration of 0.3-1.2 mg / ml. Prepared solutions can opalesce due to the carrier base present in the dosage form, and after filtration, the opalescence of the solution persists.

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Adverse reactions

• Benign, malignant and indeterminate neoplasms (including cysts and polyps): Prostate cancer (or worsening of the course of diagnosed prostate cancer);
• Blood system: Polycythemia;
• Metabolism: Fluid retention (edema);
• Central nervous system: Depression, increased nervous excitability, mood changes, increased or decreased libido;
• Musculoskeletal system: Myalgia;
• Cardiovascular system: Increased blood pressure;
• Gastrointestinal tract: Nausea;
• Skin: Itching, acne;
• Genitourinary system: Gynecomastia, oligospermia, reduced ejaculate volume, priapism, functional disorders of the prostate gland (hypertrophy).

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