Testosterone undecanoate is an ester of the natural androgen, testosterone. The active form, testosterone, is formed as a result of the cleavage of the side chain. Testosterone is the most important androgen in the male body and is synthesized mainly in the testicles and, to a lesser extent, in the adrenal cortex. Testosterone is responsible for the formation of male characteristics during intrauterine development, in early childhood, as well as during puberty, and then for maintaining the male phenotype and androgen-dependent functions (for example, spermatogenesis, sex glands). Insufficient testosterone secretion leads to male hypogonadism, which is characterized by a low concentration of testosterone in the blood serum. Symptoms associated with male hypogonadism include, but are not limited to, erectile dysfunction, decreased libido, fatigue, depressive mood, absence, underdevelopment, or regression of secondary sexual characteristics, and an increased risk of osteoporosis.
Hormone of the male sex glands. It has androgenic activity. Promotes the formation of sexual organs and the development of secondary sexual characteristics in men. In hypogonadism of various etiologies, exogenous testosterone makes up for the deficiency of endogenous hormone. Testosterone also has an anabolic effect: it stimulates protein synthesis in the body, accelerates bone calcification. It causes a delay in the body of nitrogen, potassium, calcium, sulfur, phosphates, as well as sodium, chlorine, and water. It stimulates erythropoiesis. In women, testosterone suppresses the gonadotropic function of the pituitary gland, the function of the ovaries, mammary glands, and endometrial atrophy.
Dosage Method of use
Injection of the drug Nebido (1 ampoule or bottle contains 1000 mg of testosterone undecanoate) is carried out once every 10-14 weeks. With such a frequency of injections, it is ensured that a sufficient concentration of testosterone is maintained and that there is no accumulation of the substance. The contents of the ampoule or vial should be administered intramuscularly immediately after opening. The injection should be done very slowly (about 2 minutes). The drug Nebido can only be administered strictly intramuscularly. It is necessary to carefully ensure that the injected substance does not enter the vessel. For the bottle: after removing the plastic cap, do not remove the rubber stopper rolled up with the aluminum cap. Start of treatment. Before starting treatment, the amount of testosterone in the blood serum should be determined. The first interval between injections can be shortened, but it should be at least 6 weeks. The equilibrium concentration at this dose is achieved quickly. Individual treatment adjustment. At the end of the interval between injections, it is recommended to measure the concentration of testosterone in the blood serum. If its concentration is lower than normal, then this may indicate the need to shorten the interval between injections. At high concentrations, it should be considered whether it is appropriate to increase this interval. The interval between injections should remain within the recommended range of 10 to 14 weeks.
|Active substance||Testosteron Undecanate, Testosterone|
|Active ingredient, mg||1000|
|1 bottle, ml||4|
|Ampoules per package, pcs||3|
|Packing||Ampoule, Packing (5 ampoules)|