Selective beta2-adrenostimulator, has bronchodilatory and secretolytic effects. It excites beta2-adrenergic receptors, stimulates adenylate cyclase, increases the concentration of cAMP in cells, which, acting on the protein kinase system, deprives myosin of the ability to connect with actin and promotes relaxation of the bronchi. It inhibits the release of mediators from mast cells that promote bronchospasm and bronchial inflammation. Reduces edema or congestion in the bronchi, improves mucociliary clearance. In large doses, it causes tachycardia, tremor of the fingers. The beginning of the bronchodilator effect after inhalation-after 10 minutes, maximum-after 2-3 hours, the duration of action-12 hours.
Beta-blockers are pharmacological antagonists of clenbuterol and can eliminate its effect.
Clenbuterol reduces the effect of hypoglycemic agents. Increases the risk of developing intracardiac conduction disorders when used concomitantly with MAO inhibitors and theophylline. Increases the toxicity of cardiac glycosides and increases the risk of arrhythmia. In combination with sympathomimetic agents, a mutual increase in toxicity is observed.
- Clenbuterol reduces the effect of hypoglycemic drugs.
- Clenbuterol reduces the effectiveness of antihypertensive drugs.
- The effect of clenbuterol is potentiated by tricyclic antidepressants, beta-adrenomimetics, and anticholinergics.
Halothane and other halogenated hydrocarboxylic agents for anesthesia, as well as cyclopropane, can potentiate the proarrhythmogenic effect of clenbuterol.
Inside, in the form of tablets and syrup (1 ml contains 1 mcg). When conducting long-term treatment in adults and children over 12 years of age, a dose of 10-20 mcg is prescribed 2 times a day, if necessary, it is possible to increase the dose to 8 mcg/day (until the condition improves). The daily dose for children (for 2 doses): from 6 to 12 years-15 mcg, 4-6 years-10 mcg, 2-4 years (body weight 12-16 kg) - 7.5 mcg, 8-24 months (body weight 8-12 kg) - 5 mcg, up to 8 months (body weight 4-8 kg) - 2.5 mcg.
For inhalation, use a respirator; dilute 4-7 drops of the solution in 3-5 ml of distilled water and inhale for 5-10 minutes.
|Active ingredient, mg||0,04|
|1 pill, mg||0,04|
|Blister, pills||2, 50|
|Manufacturer||Euro Prime Farmaceuticals|
|Packing||Packing (2 blisters), Blister (50 pills)|