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Anastrazole 1 mg by Magnus Pharmaceuticals is a highly selective non-steroidal agent that inhibits the properties of the aromatase enzyme. When using the properties of this drug in the female half of the population who are in the menopausal period, the amount of estradiol in the blood decreases, since the metabolism of extradiol occurs with the help of aromatase (the enzyme converts androgens into estrogens).
Effect Anastrazole 1 mg by Magnus Pharmaceuticals
The drug has the property of negatively affecting the development of oncological processes in the mammary glands. Anastrazole 1 mg Magnus Pharmaceuticals does not have the property of increasing the activity of estrogens, androgens and progestogens, and also does not affect the production of cortisol and aldosterone.
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Method of application Anastrazole by Magnus Pharmaceuticals in England
When treated with Anastrazole at the recommended dose — 1 mg per day — the level of estradiol decreases by 70% within 24 hours, by 80% - after 14 days.
Suppression of the level of estradiol in the blood serum persists for 6 days after stopping the daily intake of 1 g of anastrozole. Reducing the level of circulating estradiol has a therapeutic effect on breast tumors in postmenopausal women. When taken daily at doses of 3, 5 and 10 mg, anastrozole had no effect on the secretion of cortisol and aldosterone.
Anastrazole 1 mg did not exhibit direct progestogenic, androgenic, or estrogenic activity in animals, but it did alter the levels of circulating progesterone, androgens, and estrogens.
After ingestion, 83-85% of the dose is absorbed, food intake affects the absorption (reduces the absorption). Cmax is reached after 2 hours (on an empty stomach). In the blood, up to 40% is bound to plasma proteins.
The equilibrium concentration in the blood with a daily intake is reached after about 7 days, its value is 3-4 times higher than with a single dose. Anastrazole 1 mg by Magnus Pharmaceuticals is intensively metabolized in postmenopausal women, less than 10% is excreted unchanged in the urine within 72 hours after administration, 60% is excreted as metabolites.
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Side effects Anastrazole 1 mg
- On the endocrine system: "hot flashes", vaginal dryness and thinning of hair.
- Digestive system disorders: Anorexia, nausea, vomiting, diarrhea. In patients with advanced breast cancer, in most cases with metastases to the liver, elevated GGT levels and rarely - alkaline phosphatase were noted.
- CNS side: Asthenia, somnolence, headache.
- Metabolism disorders: slight increase in the level of total cholesterol.
- Allergic reactions: skin rash.
You can buy Anastrazole by Magnus Pharmaceuticals in England on the site of our online store.
|Active ingredient, mg||1|
|1 pill, mg||1|
|Packing||Packing (25 pills)|